A Bio-Guided Fractionation to Assess the Inhibitory Activity of Calendula officinalis L. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells.
A Bio-Guided Fractionation to Assess the Inhibitory Activity of Calendula officinalis L. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells. Evid Based Complement Alternat Med 2015;2015:727342.
Study type: In vitro (non-skin cells — indirect) · Added to this library August 23, 2026
What the researchers did
Chemical detective work: which calendula molecule carries the anti-inflammatory effect.
What they found
The triterpenoid faradiol-3-myristate blocks NF-κB from binding DNA — the core inflammation switch — at ~10 µM.
Why it matters
Calendula's "cooling" has a named molecule and a named switch.
Relates to the pattern: General (all patterns)
This summary is educational and does not replace care from your child's pediatrician. Evidence tiers matter: a finding in cells or animals is a reason a treatment could work, not proof that it does.
More in Calendula
A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in Children.
Panahi Y, Sharif MR, Sharif A, et al. A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in Children. ScientificWorldJournal 2012;2012:810234.
Study type: RCT — in infants (n=66, under 3 years)
What: Calendula ointment vs aloe vera for diaper dermatitis in babies, ten days.
Found: Both improved rash significantly; calendula left significantly fewer rash sites (p=0.001); no adverse effects in either group.
Why it matters: The best infant-safety trial data of any herbal topical we use — a randomized trial, in babies, with zero adverse events.
Phase III Randomized Trial of Calendula Officinalis Compared With Trolamine for the Prevention of Acute Dermatitis During Irradiation for Breast Cancer.
Pommier P, Gomez F, Sunyach MP, et al. Phase III Randomized Trial of Calendula Officinalis Compared With Trolamine for the Prevention of Acute Dermatitis During Irradiation for Breast Cancer. J Clin Oncol 2004;22(8):1447-1453.
Study type: RCT (phase III, n=254)
What: Calendula vs the standard cream for radiation skin damage during breast-cancer treatment.
Found: Severe dermatitis in 41% on calendula vs 63% on the comparator (p<0.001), with less pain and fewer treatment interruptions.
Why it matters: Published in oncology's flagship journal: the humble marigold salve protected skin under literal radiation better than the pharmaceutical standard.
A systematic review of Calendula officinalis extract for wound healing.
Givol O, Kornhaber R, Visentin D, et al. A systematic review of Calendula officinalis extract for wound healing. Wound Repair Regen 2019;27(5):548-561.
Study type: Systematic review (14 studies)
What: All the calendula wound-healing evidence, weighed.
Found: Consistent acceleration of the inflammatory phase and more granulation tissue in acute wounds; evidence for chronic wounds and burns mixed.
Why it matters: Calendula's lane is the acute, inflamed, healing lesion — which is exactly where we deploy it.
Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil.
Parente LML, Lino Júnior RdS, Tresvenzol LMF, et al. Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil. Evid Based Complement Alternat Med 2012;2012:375671.
Study type: Animal
What: Calendula extract in rat wounds and a blood-vessel-growth assay.
Found: More new blood vessels, less fibrin, more collagen by day 7 — and direct antibacterial activity against S. aureus.
Why it matters: The European vulnerary ("wound herb") tradition, decomposed into angiogenesis, collagen and antisepsis.